All posts by Richard Gayle

Connections that create new research areas

Science: Retrovirus Linked to Chronic Fatigue Syndrome:
[Via AAAS News – RSS Feed]

Science: Retrovirus Detected In Patients With Chronic Fatigue Syndrome-But Does It Cause the Disease?

As many as two-thirds of patients with chronic fatigue syndrome carry an infectious retrovirus in their blood cells, according to new research published in Science. But the study’s authors say it’s not clear whether the virus is the main cause or a co-conspirator in the disorder.
[More]

First, the interesting aspect of this story to me, since it illustrates how making connections can result in innovative science. This work discusses the correlation of a specific virus to CFS. This virus was first isolated in humans just a few years ago as a possible cause for a particularly virulent form of prostate cancer. How did these researchers make the connection between a virus from prostate cancer and CFS?

It turns out the virus-positive prostate cancers demonstrate an alteration in an anti-viral protein, RNase L. The CFS researchers happened to know that a similar defect was seen in CFS patients, so they just decided to see if the virus was present in their patients also. They had no reason to expect this to be the case but it was one of those connections that makes scientists go ‘Hummm.’

The data sure are exciting. The virus is Xenotrophic Murine Leukemia Virus-related Virus (XMLV). It is a retrovirus that can incorporate itself into the cellular DNA of infected people. Two-thirds of the people in the CFS cohort had detectible virus while less than 4% of the control group did. In addition, an even higher percentage of the CFS cohort had antibodies to the virus, demonstrating that they had been infected with the virus. They also showed that the virus in the plasma of infected people could continue to be infectious.

There is still a lot of work to be done to demonstrate that this virus is the cause of the disease. But we have made some real progress simply because of a seemingly random fact presented in a piece of research that ostensibly had no connection at all to CFS.

Some of the best work comes from making a connection to a bit of data that may appear to be inconsequential. Good social networks permit these bits of data to get to people that can actually do something with them.

Technorati Tags:

Thinking by design

For anyone not already in IDEO’s PR reach, Tim Brown’s presentation at TED in July has been posted. Tim does a great job talking about how design become a narrow profession—”a priesthood of folks in black turtlenecks and designer glasses working on small things.” And in talking about how design can become something more.

[More]

Design Thinking

Design thinking provides a nice model for fostering innovation. Many of my ideas deal with how to move innovations, particularly disruptive innovations, though a community.

But someone has to create the innovations to begin with.

The TED talk is wonderful because it brings a whole systems approach to the problem. Instead of thinking small and only focussing on one area, design thinking encourages people to see how everything fits together and design innovative approaches to achieve the goal.

The key is to then get these innovations adopted by the community. That can be tough.

Technorati Tags:

Turning medicine on its head

reverse by psyberartist
It’s Time to Turn to Research’s Most Valuable, Yet Underutilized Resource: Patients:
[Via FasterCures]
By Margaret Anderson, COO, FasterCures

A piece in yesterday’s New York Times, Research Trove: Patients’ Online Data, recounts the story of a young woman stricken by a rare pulmonary disease, and her attempts to raise money and connect a network of scientists to research her ailment. In collaboration with a Harvard cancer researcher, she launched a Web site for others facing her same diagnosis, on which patients could share symptoms and report health information.
[
More]

Much of our medical system uses a top-down approach, where the doctor, informed by his colleagues, current research or, most likely, pharmaceutical representatives, tells the patient what to do or what drugs to take.

But, with the access to the internet, more and more patients are telling their doctors about their ailments. They are taking a more active role in their therapies. online tools now make it even easier.

Patients can now organize around diseases, raise money and work for therapies in ways that could actually change the entire paradigm of medical research. What happens when medicine becomes patient-driven, where the responsibility shifts?

It could be very problematic, since many people really do not want to be active. they want the doctor to tell them what to do in order to become well. Many doctors are effectively trained to respond in this way. But some people are seeking a different approach. It will be interesting to see if social media approaches can alter the current paradigm and to what extent.

Technorati Tags: ,

Scientists need to tell better stories

space stories by jurvetson
Stories Can Change The World:
[Via BIF Speak]

“Facts are facts, but stories are who we are, how we learn, and what it all means.” My friend Alan Webber, Co-founder of Fast Company and author of Rules of Thumb, has it exactly right. Storytelling is the most important tool for any innovator.

[More]

Scientists may not always realize it but they are always telling stories, providing narratives to illustrate the point to their research. This is often missed because the form the narrative takes is so structured that it does not appear like any story most of us have read.

But a story it is. It may be “Here is something no one has ever seen before and we don’t know what is going on.” Or “After years of work, we have completely delineated how this disease progresses.” Or “Here is an important piece to the puzzle that has been giving us fits for such a long time.” Or, sometimes, “What everyone else has written before is completely wrong and we show why!”

As a graduate student, I first ran across the expression, when putting a paper together, was “What story do we want to tell?” Few non-scientists really understand that every paper is simply a narrative. The best ones are incredible stories.

The structure of a paper throws many people off. There is an abstract, background, materials and methods, results and conclusions. It does not look like a standard text, it is presented in a stilted fashion and it has a structure that is unfamiliar but it actually does have a beginning, middle and end.

The abstract acts like a blurb on the back of a book, telling us whether the paper is worth reading. The background and methods act like a preface, giving us informative background.

The results are the meat of the story. Most start small, building up the knowledge as they move to data that have greater and greater ramifications. This leads to the climax of the paper, where they can state what it is they have now proven.

The conclusions often function as a denouement, recapitulating the action and providing context. It can also set up the action for the sequel.

Anyone reading Watson and Crick’s classic paper on the structure of DNA can see that it is a story. In fact, it compresses much of the normal scientific narrative in order to provide one of the classic “We figured it all out before everyone else!” stories.

It starts off with what others have proposed, continues with their model, demonstrates just how much better this fits all the data, and then ending with these words, setting up everything for the next series of papers:

It has not escaped our notice that the specific pairing we have postulated immediately suggest a possible copying mechanism for the genetic material.

Full details of the structures, including the conditions assumed in building it, together with a set of co-ordinates for the atoms, will be published elsewhere.

Science papers have an unusual format but they follow some of the standard things we see in any story. There has to a point to the paper. Why would anyone want to read the paper? It ca not just be a collection of random facts. The paper has to lead to some firm conclusions, including possible ramifications for current studies..

It must be focussed. It cannot meander through a lot of side streams. A science paper has to be kept on a very tight leash.

In every paper I have written, I have had to toss out very good experimental data, data that have no problems, because that they really do not fit the narrative that drives us to the conclusion. A well written paper focuses on the point and does not provide side trips into other areas.

The DNA paper did all this in one page. It left the detours for another time.

Most scientists realize at some level that a paper has to tell a story. But they do not realize that a scientific presentation at a conference really must do the same. There needs to be a beginning, middle and end. There has to be a point to it all, providing context to the data and its place in Nature.

Too many scientists forget this. They provide no frame for the discussion, leave needed background out and dump in all the data that was not fit for the focussed needs of a papers. Thus, most scientific presentations are unfocussed and boring. No structure and no real point.

The best presentations, the ones we all remember, use the data to provide a narrative, to help us understand just what story they are trying to tell.

We all tend to learn the needed tools to write a good science paper, incorporating the idea of a proper narrative. But few are provided any real tools to apply to presentations before a group of people. Most never learn the proper tools and simply give boring talk after boring talk.

Learning how to tell better stories, not just write good narratives, is something al researchers should learn how to do. But, whereas there is a real premium put on writing good papers, there is little pressure to speak well before a group.

That is why the best places to be at scientific conferences is usually not at the presentations but at the bars and pubs frequented by the conference goers. We get the real story there because every human being knows how to trade stories with others, even when the group is just a bunch of researchers.

Now if we could just get more researchers to adopt this approach to their public speaking trips, we might affect some real change.

Technorati Tags:

Tell stories

storytelling by Rusty Darbonne
Explainer Tip: Remember the Curse of Knowledge:
[Via Common Craft – Explanations In Plain English –]

One of the books that I read just before creating our first videos was Made to Stick by Chip and Dan Heath. More than almost any other, this book helped me see new opportunities to present ideas in a unique way. One idea from the book really stands out – it’s The Curse of Knowledge <insert scary music.>

We’ve all experienced it – in talking to a doctor, an engineer or academic, we get lost. Despite their best efforts, they explain a topic using words and examples that don’t make sense to a beginner. These people are suffering from the Curse.

The idea behind the curse of knowledge is that the more we know about something, the harder it is for us to explain it to someone who knows nothing. We have a hard time being able to imagine what it’s like not to know. For example, think about a lawyer who spent his life reading and writing legal documents, talking to lawyers all day every day, etc. When you ask this lawyer about tort reform, you’re likely to get an explanation that confuses you more. This person knows too much to answer your question in a language you understand.

We’re all guilty of having the curse. We all have something in our life that we know very well – perhaps too well to explain easily. The key is know that the curse exists. To be able to recognize the challenge before you. Here’s how:

Consider every word. Sometimes a word that is completely natural to you can doom an explanation. For example, let’s say you’re a financial planner and you sit down with a young couple and they seem to get everything you’re saying. Then you mention “amortization” as if it were any other word. You use it every day and the people around you do too. It may seem that amortization is perfectly normal. But it’s not – their eyes glaze over and the explanation takes a turn for the worst. You have the curse.

[More]

What Common Craft does is tell great stories. This is the easiest model for communication between diverse communities that may not have a common language.

Communities tend to develop language, slang and even stories that really only promote communication within the group. Jargon is used to separate those in the know with those who are outsiders. It can be used to tell who is in and who is out.

If an organization want to interact, if it wants to collaborate, it has to destroy jargon, it has to create common stories that permit understanding to take hold.

Most of what we deal with every day is really too complex to easily discuss and evaluate without years of experience and lots of jargon. In fact, few people actually think like that. They create heuristics, rules of thumb, that permit them to deal with complexity.

in many cases, these heuristics can be exemplified by stories and metaphor. When people view their speech as stories, they often make the sort of simplifying changes that are needed for effective communication with those outside the group.

Because stories often are used to communicate very complex ideas but in terms that anyone can understand. Watch any Common Craft video.

Technorati Tags: ,

Systems thinking

Systems Thinking: Ancient Maya’s Evolution of Consciousness and Contemporary Thinking:
[Via Ackoff Center Weblog]

Posted by Assistant Professor Tadeja Jere Lazanski, University of Primorska, Portoroz, Slovenia on his blog: “Systems thinking is a framework that is based on the belief that the component parts of a system can best be understood in the context…

[More]

I may not hold with all the aspects of this model but it certainly could be a nice starting point for an interesting conversation of using synthetic approaches to solve problems. At least now I can understand why I should be excited about 2012.

Technorati Tags: ,

I’ve been thinking

I’ve taken a little break reading and thinking. I’ve spent the last few days working on some ideas regarding the traversal of innovations across a community and then working on the data to support these ideas. I’m really excited by some of the information my model fits now.

I’m developing a process that will help an organization whose business depends on innovations. I hope to have a set of tools based on published data that will facilitate the adoption of change. I’ll be writing about these over the coming weeks.

I’ll also get back to blogging. Should be fun.

Technorati Tags:

Using crowds to solve problems

crowd by James Cridland
Get Ready to Participate: Crowdsourcing and Governance:
[Via Confessions of an Aca/Fan]

Crowdsourcing and Governance

by Daren C. Brabham

It’s been three years since Jeff Howe coined the term “crowdsourcing” in his Wired article “The Rise of Crowdsourcing.” The term, which describes an online, distributed problem solving and production model, is most famously represented in the business operations of companies like Threadless and InnoCentive and in contests like the Goldcorp Challenge and the Doritos Crash the Super Bowl Contest.

In each of these cases, the company has a problem it needs solved or a product it needs designed. The company broadcasts this challenge on its Web site to an online community–a crowd–and the crowd submits designs and solutions in response. Next–and this is a key component of crowdsourcing–the crowd vets the submissions of its peers, critiquing and ranking submissions until winners emerge. Though winners are often rewarded for their ideas, prizes are often small relative to industry standards for the same kind of professional work and rewards sometimes only consist of public recognition.

Recognizing that not all creativity and innovation resides in-house, some organizations are looking for connections to outside innovators. New social tools allow them to make connections, through such sources as InnoCentive. When done well, these approaches can not only produce new ideas but help vet these ideas for suitability.

This approach can work in areas other than for-profit settings. Think non-profit biomedical institutions or government.

Though you’d be hard pressed to see them ever use the word “crowdsourcing,” one such example of crowdsourcing in governance is Peer-to-Patent. Begun in June 2007, Peer-to-Patent is a project developed by New York Law School’s Institute for Information Law and Policy, in cooperation with the U.S. Patent and Trademark Office (USPTO). The pilot project engages an online community in the examination of pending patent applications, tasking the crowd with identifying prior art and annotating applications to be forwarded on to the USPTO. The project helps to streamline the typical patent review process, adding many more sets of eyes to a typical examination process.

Another attempt to use crowdsourcing in public decision-making is Next Stop Design, a project with which I am involved that asks the crowd to design a bus stop for Salt Lake City, Utah. With Thomas W. Sanchez and a team of researchers from the University of Utah, we’re working in cooperation with the Utah Transit Authority (UTA) and funded by a grant from the U.S. Federal Transit Administration. On the Next Stop Design Web site, you can register for free, submit your own bus stop designs and ideas, and rate and comment on the designs of others. Launched on June 5, 2009, the project runs through September 25, 2009, and the highest rated designs will be considered for actual construction at a major bus transfer stop in Salt Lake City. Winning designs will be publicly acknowledged and included on a plaque affixed to the built bus stop.

It will take some changes in viewpoints but the ability of the public to directly engage important aspects of government should only enhance policy. Obviously, this approach could not be used in every area but careful positioning of the approach could have real consequences.

There is much potential for crowdsourcing in government, certainly as one of an array of social media methods quickly being embraced by all levels of government. President Obama has made his intentions with technology and transparency in government clear. His appointment of Beth Noveck, the New York Law School professor who launched Peer-to-Patent, as Deputy Chief Technology Officer for Open Government, makes his intentions very clear. I predict over the next two years we’ll see in the U.S. a rapid proliferation of government by the crowd, for the crowd. Get ready to participate.

It will be interesting to see if this approach also harnesses some of the social commitments seen in the Millennials. This generation is already connected and has shown some strong willingness to work on social needs. I think that the impact of these approaches may be greater in non-profit settings than in for-profit. By engaging people in the charitable work in ways that easily make them a part of the process, non-profits have an advantage that few for-profits do.

Technorati Tags:

Some new stuff

If you look over to the far righthand column under information, you will see several new pages on the website. I’ve had these online for a while but have only just recently figured out how to get them formatted and in the proper order for the Information column.

The new pages deal with Diffusions of Information in a Community. They provide a stp by step understanding of how data becomes knowledge, how individuals chose to adopt an innovation and how these changes then traverse a community.

They should distill a lot of information into reasonable sizes and make it easier to understand the process. There are also links to PDF versions of each.

Enjoy

Innovating with elephants

Energy, innovation and elephants:
[Via Andrew Hargadon]

There’s nothing like money to bring out the dogma in people, and there’s nothing, if not money, in the $150B energy innovation plan of the Obama administration.

The ensuing dogma surfaces around how to best spend that money. On the one side are those arguing that we need to invest in deploying existing technologies (the latest in solar, wind, and energy efficiency)—on the other side are those arguing such federal investments in existing technologies would starve the basic research activities that will bring us the truly breakthrough technologies we need. Nowhere is this debate more starkly represented than in the (barely) civil dialog between Joe Romm and the Breakthrough Institute. Andy Revkin, of the NYT and his blog, Dot Earth, describes this debate:

[More]

A really nice discussion of two important viewpoints. And the metaphor of the blind men and the elephant is one of my favorites.

Because collaboration can help us gain a truer understanding of the world than a single view. If the blind men talked with each other, then they could actually describe an elephant. Just as more open discussion could provide a better understanding of where to put the money.

But respect for other views is a requirement for this to work. If the blind men went around saying all the other views were full of crap, then no real understanding could occur. Same with these sorts of discussions.

Technorati Tags: ,